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Cancer Discovery, September 2021

Pharmacological activation of p53 triggers viral mimicry response thereby abolishing tumor immune evasion and promoting anti-tumor immunity

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Publication highlighted in The Scientist

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Cancer Clinical Research, July 2021

Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-Type TP53

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2019 ESMO Congress

ALRN-6924 and Palbociclib in Patients with MDM2 Amplified or MDM2/CDK4 Co-amplified Tumors: Interim Analysis

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Nature Communications, May 2018

Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models

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Science Translational Medicine, April 2018

Dual inhibition of MDMX and MDM2 as a Therapeutic Strategy in Leukemia

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Publication highlighted in The Hematologist

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2018 ASH Annual Meeting and Exposition

Preliminary Results of the Stapled Peptide ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Two Phase IIa Dose Expansion Cohorts in Relapsed/Refractory TP53 Wild-Type Peripheral T-Cell Lymphoma

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Phase 1/1b Study of the Stapled Peptide ALRN-6924, a Dual Inhibitor of MDMX and MDM2, As Monotherapy or in Combination with Cytarabine for the Treatment of Relapsed/Refractory AML and Advanced MDS with TP53 Wild-Type

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2018 San Antonio Breast Cancer Symposium

The stapled peptide ALRN-6924, a dual inhibitor of MDMX and MDM2, and the CDK4/6 inhibitors palbociclib or abemaciclib synergistically enhance each other’s in vitro and in vivo anticancer activity

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The stapled peptide ALRN‐6924, a dual inhibitor of MDMX and MDM2, enhances antitumor efficacy of paclitaxel and Nab‐paclitaxel in TP53 wild‐type MCF‐7 breast cancer models

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2018 EORTC-NCI-AACR Molecular Targets And Cancer Therapeutics Symposium

Harnessing the anticancer activity of the stapled peptide ALRN-6924, a dual inhibitor of MDMX and MDM2, using rational combination strategies for breast cancer and other malignancies

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2018 Society for Immunotherapy of Cancer (SITC) Annual Meeting

The stapled peptide ALRN-6924, a dual inhibitor of MDMX and MDM2, displays immunomodulatory activity and enhances immune checkpoint blockade in syngeneic mouse models

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2017 ASH Annual Meeting and Exposition

In Vitro and Preclinical In Vivo Evidence Support MDMX/MDM2 as Common Vulnerabilities Across TP53-Wild-Type T-Cell Lymphomas That Are Targetable with the Alpha-Helical P53 Stapled Peptide ALRN-6924

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Dual Inhibition of MDMX and MDM2 Using an Alpha-Helical P53 Stapled Peptide (ALRN-6924) As a Novel Therapeutic Strategy in Acute Myeloid Leukemia

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2017 ASCO Annual Meeting

Phase I trial of a novel stapled peptide ALRN-6924 disrupting MDMX- and MDM2-mediated inhibition of WT p53 in patients with solid tumors and lymphomas

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Abstract highlighted in Journal of Clinical Oncology (ASCO Special article)

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